People who act just plain weird when they are in public or as characters in a show get the label of autism and most likely Asperger’s. Zach Galifinakis is an actor who has played some very strange characters, but the actor himself does not seem to be on the autism register. His character in “Bachelor Party” and other roles may seem a bit extreme, but this would lead one to think about the opposite of autism. He may be a bit manic though. This seems more the case than that he could be autistic. So, no he is probably not autistic.